We requested a few of our prime researchers to share their private ambitions for 2019 and the important thing traits that they hope to see emerge of their subject.
Professor Karen Vousden – Most cancers Analysis UK’s chief scientist
Professor Karen Vousden has spent the final 30 years in most cancers analysis finding out some of the vital molecules in most cancers, known as p53. She was director of our Beatson Institute in Glasgow from 2003 till two years in the past, when she was appointed Most cancers Analysis UK’s chief scientist. In 2019, Vousden is trying ahead to understanding extra about how altering weight loss program can have an effect on most cancers remedy.
One of many areas we’re desirous about is whether or not we are able to use outlined diets to spice up the effectiveness of therapies like chemotherapy. This method is dependent upon an in depth understanding of how most cancers cells feed themselves. Analysis by us and others has proven that most cancers cells are extremely depending on a provide of some amino acids, together with one known as serine. And we’ve discovered that we are able to gradual tumour progress in mice given a weight loss program that doesn’t include this amino acid. Now we’re actually desirous about making an attempt to maneuver this work into folks to see if the identical factor applies.
Our final intention is to run a scientific trial testing if a particular weight loss program that lacks serine may also help sufferers having chemotherapy, however first we have to check the weight loss program in wholesome volunteers. This yr we hope to search out out if it’s potential to cut back the quantity of serine circulating within the physique by placing somebody on a particular weight loss program, as it’s in mice. We’ll even be operating extra experiments with mice to see if this restricted weight loss program has any surprising affect on the remainder of the physique, notably the immune system.
Past my work I’m actually enthusiastic about what we’ll study immunotherapy in 2019. The concept we are able to reactivate the physique’s means to detect and kill most cancers cells utilizing these new therapies has been a sport changer lately. However whereas it’s had astonishing outcomes for some folks, others don’t reply in any respect. So in addition to trying to develop new approaches, I hope the following few years will carry a deeper understanding of why just some sufferers’ cancers reply to this kind of remedy.
Lastly, there’s so much to stay up for at Most cancers Analysis UK. I’m notably excited by a few of the formidable initiatives which are being arrange for the time being. We’re bringing collectively proficient folks from all over the world and from plenty of totally different areas of science to sort out a few of the massive questions in most cancers analysis. And that opens up some vastly thrilling prospects.
We’ll be updating this submit all through the week. Tomorrow, Professor Karl Peggs, a clinician and researcher at College School London, shares what to look out for in immunotherapy in 2019.
Gabi, Katie & Ethan